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Pectus excavatum - CPR-1000 Current Probe Reader - china HUS-1000 Test Bench

Signs and symptoms The hallmark of the condition is a sunken appearance of the sternum. The heart can be displaced and/or rotated. Mitral valve prolapse may also be present. Base lung capacity is decreased. Causes Researchers are currently unsure as to the actual cause of pectus excavatum but hypothesize genetic defect. Approximately 37% of individuals with pectus excavatum have a first degree family member with the condition. Physiologically, increased pressure in utero, rickets and increased traction on the sternum due to abnormalities of the diaphragm have been postulated as specific mechanisms.

Pectus excavatum is also a relatively common symptom of Marfan syndrome. Many children with Spinal Muscular Atrophy develop pectus excavatum due to the diaphragmatic breathing that is common with the disease. Pathophysiology Because the heart is located behind the sternum, and because individuals with pectus excavatum have been shown to have visible deformities of the heart (seen both on radiological imaging and after autopsies), it has been hypothesized that there is impairment of function of the cardiovascular system in individuals with pectus excavatum. While some studies have demonstrated decreased cardiovascular function in pectus excavatum, there has been no consensus reached based on newer physiological tests (such as echocardiography) of the presence or degree of impairment in cardiovascular function in people with pectus excavatum. Similarly, there is no consensus on the degree of functional improvement after corrective surgery. Diagnosis Cross sectional scan of a chest with pectus excavatum Pectus excavatum is initially suspected from visual examination of the anterior chest. Auscultation of the chest can reveal displaced heart beat and valve prolapse. There can be a heart murmur occurring during systole caused by proximity between the sternum and the pulmonary artery. Lung sounds are usually clear yet diminished due to decreased base lung capacity. Many scales have been developed to determine the degree of deformity in the chest wall. Most of these are variants on the distance between the sternum and the spine. One such index is the Backer ratio which grades severity of deformity based on the ratio between the diameter of the vertebral body nearest to xiphosternal junction and the distance between the xiphosternal junction and the nearest vertebral body. More recently the Haller index has been used based on CT scan measurements.

An index over 3.25 is often defined as severe. The Haller index is the ratio between the horizontal distance of the inside of the ribcage and the shortest distance between the vertebrae and sternum. Chest x-rays are also useful in the diagnosis. The chest x-ray in pectus excavatum can show an opacity in the right lung area that can be mistaken for an infiltrate (such as that seen with pneumonia). Some studies also suggest that the Haller index can be calculated based on chest x-ray as opposed to CT scanning in individuals who have no limitation in their function. Pectus excavatum is differentiated from other disorders by a series of elimination of signs and symptoms. Pectus carinatum is excluded by the simple observation of a collapsing of the sternum rather than a protrusion. Kyphoscoliosis is excluded by diagnostic imaging of the spine, where in pectus excavatum the spine usually appears normal in structure. Treatment Treatment for pectus excavatum can involve either invasive or non-invasive techniques or a combination of both. Before an operation proceeds several tests are usually to be performed. These include, but are not limited to, a CT scan, pulmonary function tests, and cardiology exams (such as auscultation and ECGs). After a CT scan is taken the Haller index is measured. The patient's Haller is calculated by obtaining the ratio of the transverse diameter (the horizontal distance of the inside of the ribcage) and the anteroposterior diameter (the shortest distance between the vertebrae and sternum).

A Haller Index of greater than 3.25 is generally considered severe, while normal chest has an index of 2.5. The cardiopulmonary tests are used to determine the lung capacity and to check for heart murmurs. Surgery Surgical correction has been shown to repair any functional symptoms that may occur in the condition, such as respiratory problems or heart murmurs, provided that permanent damage has not already arisen from an extremely severe case. Ravitch technique The Ravitch technique is an invasive surgery that was introduced in 1949, and developed in the 1950s to treat the condition. This procedure involves creating an incision along the chest through which the cartilage is removed and the sternum detached. A small bar is then inserted underneath the sternum to hold it up in the desired position.

The bar is left implanted until the cartilage grows back, typically about 6 months. The bar is subsequently removed in a simple out-patient procedure. The Ravitch technique is not widely practiced because it is so invasive. It is often used in older patients, where the sternum has calcified, when the deformity is asymmetrical, or when the less invasive Nuss procedure has proven unsuccessful.[citation needed] Nuss procedure Main article: Nuss procedure Lung exercisers, used after corrective surgery to avoid pneumonia and increase base lung capacity X-Ray of a 15 year old male after undergoing the Nuss procedure Since then, Dr. Donald Nuss, based at Children's Hospital of The King's Daughters (CHKD) in Norfolk, Virginia, has developed a technique that is minimally invasive. The Nuss procedure involves slipping in one or more concave steel bars into the chest, underneath the sternum. The bar is flipped to a convex position so as to push outward on the sternum, correcting the deformity. The bar usually stays in the body for about two years, although many surgeons are now moving toward leaving them in for up to five years. When the bones have solidified into place, the bar is removed through outpatient surgery. Vacuum bell and Rib compressor Main article: Vacuum bell (medicine) A relatively new alternative to surgery is the vacuum bell. It consists of a bowl shaped device which fits over the caved-in area; the air is then removed by the use of a hand pump.

The vacuum created by this lifts the sternum upwards, lessening the severity of the deformity. As it is such a recent device there is currently no information as to whether it is effective in the long term. The use of the Rib Compressor along with the use of a 7" suction device has proven effective in permanently correcting pectus excavatum. The ribs are compressed while the sternum is lifted by a small 7" suction device this sets the ribs into the desired position and thus corrects the postition of the sternum. Cosmetic and light treatments The cosmetic appearance of pectus excavatum can be treated with a dermal filler called Bio-Alcamid. However, as this does nothing to alleviate the actual deformity it will not prevent any physiological symptoms caused by the condition. Mild cases have also reportedly been treated with corset-like orthopedic support vests and exercise. There are also prosthetic implants available to fill the depressed area. Solid silicone implants have been successfully used for many years with acceptable results in some cases. More recently a porex implant has been used which is a similar material used to replace skull in brain surgery and severe head injuries. Magnetic mini-mover procedure The magnetic mini-mover procedure (3MP) is a technique used to correct pectus excavatum by using two magnets to realign the sternum with the rest of the chest and ribcage. One magnet is inserted 1 cm into the patients body on the lower end of the sternum, the other is placed externally onto a custom fitted brace. These two magnets generate around 0.04 tesla (T) in order to slowly move the sternum outwards over a number of years. The maximum magnetic field that can be applied to the body safely is around 4 T, making this technique safe from a magnetic viewpoint. The 3MP technique's main advantages are that it is more cost-effective than major surgical approaches such as the Nuss procedure and it is considerably less painful postoperatively.

One potential adverse effect of 3MP is inactivation of implanted devices such as an artificial pacemaker. Since the 3MP is still in a trial period it is unknown whether long term wearing of the magnet will affect the skin or other vital organs. Epidemiology Pectus excavatum occurs in an estimated 1 in 150-1000 births, with male predominance (male-to-female ratio of 3:1). Occurrences of the condition in family members have been reported in 35% to 45% of cases. In animals Pectus excavatum is also known to occur in animals, e.g. the Munchkin breed of cat. Some procedures used to treat the condition in animals have not been used in humans, such as the use of a cast with sutures wrapped around the sternum and the use of internal and external splints. These techniques are generally used in immature animals with flexible cartilage. See also Pectus carinatum References ^ chief lexicographer: Douglas M. Anderson (2003), Pectus Excavatum (28 ed.), Dorland's Medicla Dictionary: Saunders, ISBN 0721601464, http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/nine/000955637.htm  ^ a b c d Shamberger RC (1996). "Congenital chest wall deformities". Curr Probl Surg 33 (6): 469542. doi:10.1016/S0011-3840(96)80005-0. PMID 8641129.  ^ a b c d Crump HW (1992). "Pectus excavatum". Am Fam Physician 46 (1): 1739. PMID 1621629. http://web.archive.org/web/20071007004245/http://findarticles.com/p/articles/mi_m3225/is_n1_v46/ai_12450746.  ^ "Pectus excavatum". MedLine Plus Medical Encyclopedia. U.S. National Library of Medicine and the National Institutes of Health. 2007-11-12. http://www.nlm.nih.gov/medlineplus/ency/article/003320.htm#Considerations.  ^ "Pectus Excavatum". http://www.fpnotebook.com/Lung/Exam/PctsExcvtm.htm.  ^ Spence, Roy A. J.; Patrick J. Morrison (2005). Genetics for Surgeons. Remedica Publishing. ISBN 1-901346-69-2. http://www.ncbi.nlm.nih.gov/books/bv.fcgi?highlight=Pectus excavatum&rid=gfs.section.344.  ^ a b c "eMedicine  Pectus Excavatum". Andre Hebra. http://emedicine.medscape.com/article/1004953-overview.  ^ "eMedicine  Marfan Syndrome". Harold Chen. http://emedicine.medscape.com/article/946315-overview.  ^ Guller B, Hable K (1974). "Cardiac findings in pectus excavatum in children: review and differential diagnosis". Chest 66 (2): 16571. doi:10.1378/chest.66.2.165. PMID 4850886. http://www.chestjournal.org/cgi/reprint/66/2/165.  ^ BACKER OG, BRUNNER S, LARSEN V (1961). "The surgical treatment of funnel chest. Initial and follow-up results". Acta Chir Scand 121: 25361. PMID 13685690.  ^ Jeannette Diana-Zerpa; Nancy Thacz Browne; Laura M. Flanigan; Carmel A. McComiskey; Pam Pieper (2006). Nursing Care of the Pediatric Surgical Patient (Browne, Nursing Care of the Pediatric Surgical Patient). Sudbury, Mass: Jones & Bartlett Publishers. p. 253. ISBN 0-7637-4052-7.  ^ a b Haller JA, Kramer SS, Lietman SA (1987). "Use of CT scans in selection of patients for pectus excavatum surgery: a preliminary report". J. Pediatr. Surg. 22 (10): 9046. doi:10.1016/S0022-3468(87)80585-7. PMID 3681619. http://linkinghub.elsevier.com/retrieve/pii/S0022346887000277.  ^ Hoeffel JC, Winants D, Marcon F, Worms AM (1990). "Radioopacity of the right paracardiac lung field due to pectus excavatum (funnel chest)". Rontgenblatter 43 (7): 298300. PMID 2392647.  ^ Mueller C, Saint-Vil D, Bouchard S (2008). "Chest x-ray as a primary modality for preoperative imaging of pectus excavatum". J. Pediatr. Surg. 43 (1): 713. doi:10.1016/j.jpedsurg.2007.09.023. PMID 18206458.  ^ "How the Haller is measured. Departament of Cardiology and Pulmonology of the Hospital das Clnicas da Faculdade de Medicina da Universidade de So Paulo Thoracic Surgery Sector" (PDF). http://www.scielo.br/pdf/jbpneu/v30n6/en_a03v30n6.pdf.  ^ "The Nuss procedure for pectus excavatum correction". Barbara Swoveland, Clare Medrick, Marilyn Kirsh, Kevin G. Thompson, Nussm Donald. http://findarticles.com/p/articles/mi_m0FSL/is_6_74/ai_81218971.  ^ "Pectus Excavatum overview" (PDF). CIGNA. http://www.cigna.com/customer_care/healthcare_professional/coverage_positions/medical/mm_0309_coveragepositioncriteria_surgical_treatment_chest_wall_deformities.pdf.  ^ Ravitch MM (April 1949). "The operative treatment of pectus excavatum". Ann Surg 129 (4): 42944. doi:10.1097/00000658-194904000-00002. PMID 17859324.  ^ Nuss D, Kelly RE Jr, Croitoru DP, Katz ME (April 1998). "A 10-year review of a minimally invasive technique for the correction of pectus excavatum". J Pediatr Surg 33 (4): 54552. doi:10.1016/S0022-3468(98)90314-1. PMID 9574749.  ^ Pilegaard, HK; Licht PB (February 2008). "Early results following the Nuss operation for pectus excavatum--a single-institution experience of 383 patients". Interactive Cardiovascular and Thoracic Surgery (Oxford University Press) 7 (1): 5457. doi:10.1510/icvts.2007.160937. PMID 17951271. http://icvts.ctsnetjournals.org/cgi/content/full/7/1/54. Retrieved 2008-04-18.  ^ Haecker, FM; Mayr J (April 2006). "The vacuum bell for treatment of pectus excavatum: an alternative to surgical correction?". European Journal of Cardiothoracic Surgery 29 (4): 557561. doi:10.1016/j.ejcts.2006.01.025. PMID 16473516.  ^ Lahiri, A; Waters R (February 2007). "Experience with Bio-Alcamid, a new soft tissue endoprosthesis". Journal of Plastic, Reconstructive & Aesthetic Surgery 60 (6): 663667. doi:10.1016/j.bjps.2006.07.010. PMID 17485056.  ^ "Orthopectus". Dr. Sydney A. Haje, Ortopedista. http://www.orthopectus.com.br/fmethod.htm.  ^ Saour S, Shaaban H, McPhail J, McArthur P (September 2007). "Customised silicone prostheses for the reconstruction of chest wall defects: technique of manufacture and final outcome". J Plast Reconstr Aesthet Surg 61: 1205. doi:10.1016/j.bjps.2007.07.019. PMID 18178533. http://linkinghub.elsevier.com/retrieve/pii/S1748-6815(07)00405-6. Retrieved 2008-08-21.  ^ Wechselberger G, Ohlbauer M, Haslinger J, Schoeller T, Bauer T, Piza-Katzer H (November 2001). "Silicone implant correction of pectus excavatum". Ann Plast Surg 47 (5): 48993. doi:10.1097/00000637-200111000-00003. PMID 11716258. http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0148-7043&volume=47&issue=5&spage=489. Retrieved 2008-08-21.  ^ Grappolini S, Fanzio PM, D'Addetta PG, Todde A, Infante M (January 2008). "Aesthetic treatment of pectus excavatum: a new endoscopic technique using a porous polyethylene implant". Aesthetic Plast Surg 32 (1): 10510. doi:10.1007/s00266-007-9025-6. PMID 17851713.  ^ a b Harrison, MR; Estefan-Ventura D, Fechter R et al. (January 2007). "Magnetic Mini-Mover Procedure for pectus excavatum: I. Development, design, and simulations for feasibility and safety" (PDF). Journal of Pediatric Surgery 42 (1): 8185. doi:10.1016/j.jpedsurg.2006.09.042. PMID 17208545. http://pedsurg.ucsf.edu/media/92580/pectus_article.pdf. Retrieved 2008-04-23.  ^ "Pectus Excavatum: Frequently Asked Questions: Surgery: UI Health Topics". Harold M. Burkhart and Joan Ricks-McGillin. http://www.uihealthcare.com/topics/medicaldepartments/surgery/pectusexcavatum/index.html.  ^ "Genetic Anomalies of Cats". http://www.messybeast.com/gene-anomalies.htm.  ^ Fossum, TW; Boudrieau RJ, Hobson HP, Rudy RL (1989). "Surgical correction of pectus excavatum, using external splintage in two dogs and a cat". J. Am. Vet. Med. Assoc. 195 (1): 917. PMID 2759902.  ^ Risselada M, de Rooster H, Liuti T, Polis I, van Bree H (2006). "Use of internal splinting to realign a noncompliant sternum in a cat with pectus excavatum". J. Am. Vet. Med. Assoc. 228 (7): 104752. doi:10.2460/javma.228.7.1047. PMID 16579783. http://avmajournals.avma.org/doi/abs/10.2460/javma.228.7.1047.  ^ McAnulty JF, Harvey CE (1989). "Repair of pectus excavatum by percutaneous suturing and temporary external coaptation in a kitten". J. Am. Vet. Med. Assoc. 194 (8): 10657. PMID 2651373.  External links Wikimedia Commons has media related to: Pectus excavatum Look up pectus in Wiktionary, the free dictionary. Pectus excavatum at the Open Directory Project v  d  e Congenital malformations and deformations of musculoskeletal system / musculoskeletal abnormality (Q65-Q76, 754-756.3) Limb/ dysmelia Upper clavicle/shoulder: Cleidocranial dysostosis  Sprengel's deformity  Wallis Zieff Goldblatt syndrome hand deformity: Madelung's deformity  Clinodactyly  Oligodactyly  Polydactyly Lower hip: Dislocation of hip/Hip dysplasia  Upington disease  Coxa valga  Coxa vara knee: Genu valgum  Genu varum foot deformity: Club foot  Flat feet  Pes cavus  Rocker bottom foot Either/both dactyly/digit: Polydactyly/Syndactyly (Webbed toes)  Arachnodactyly  Cenani Lenz syndactylism  Ectrodactyly  Brachydactyly reduction deficits/limb: Acheiropodia  ectromelia (Phocomelia, Amelia, Hemimelia) multiple joints: Arthrogryposis  Larsen syndrome  Rapadilino syndrome Craniofacial Craniosynostosis: Scaphocephaly  Oxycephaly  Trigonocephaly Craniofacial dysostosis: Crouzon syndrome  Hypertelorism  Hallermann-Streiff syndrome  Treacher Collins syndrome other: Macrocephaly  Platybasia  Craniodiaphyseal dysplasia  Dolichocephaly  Greig cephalopolysyndactyly syndrome  Plagiocephaly  Saddle nose Other axial spine: spinal curvature (Scoliosis)  Klippel-Feil syndrome  Spondylolisthesis  Spina bifida occulta ribs: Cervical rib  Bifid rib sternum: Pectus excavatum  Pectus carinatum joint navs: anat, non-congenital arthropathies/deformities/dorsopathies/soft tissue arthropathy/congenital, eponymous signs, proc Categories: Musculoskeletal disorders | Congenital disorders | Human appearance | Congenital disorders of musculoskeletal systemHidden categories: All articles with unsourced statements | Articles with unsourced statements from June 2008

 

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